Text 1308, 52 rader
Skriven 2005-01-03 06:32:00 av Cncabej (1:278/230)
Ärende: Re "GENES ARE FOLLOWERS N
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Peter F. wrote:

N.C. wrote:
<snip>
>>Next we are going to show the structure and functioning of the epigenetic
>>system of heredity with the CNS at its core.

P.F.:
>I have been led to believe there are various evidence that 
>there has to exist a complementary/different molecular mechanism
>of heritability, other than that which is provided by DNA
>(and even it is in the process of being found to be very much more intricate
that >was thought even not so long ago).

NRC:
While agreeing with you on the existence of a mechanism of heredity that
is "complementary/different" to/from the  genetic mechanism of heredity, it is
essential for the epigenetic theory of heredity to point out that the genetic
mechanism of heredity, which is still operative in metazoans at the cell level,
is SUBORDINATE, i.e. is under control of the epigenetic system of heredity.

PF:
>- I have dared to pipe up to promote and relay
>the idea that microstructures of chromatin ("the histone code") might be where
>the main extra (seemingly also needed - besides EPT - to more completely
>explain how we are) "epigenetic" heritability resides.

NRC:
I am enough open-minded and accepting the existence of  a "histone code" would
not be incompatible (to the contrary) with my epigenetic theory of heredity
if/when it is experimentally demonstarted. However, I have to reiterate that
according to  my theory, and supported by adequate experimental evidence, 

- all the information for expression of (10-15,000) nonhousekeeping genes in
metazoans comes from the brain in the form of chemical signals that start
signal cascades (and histones represent downstream elements of signal
cascades), and
- all that epigenetic information is computationally generated in the CNS, as I
have earlier shown (and would be still willing to do).

Thank you for your thought-provoking input.

Nelson R. Cabej
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