Text 21665, 62 rader
Skriven 2008-10-08 13:02:43 av Roy Witt (1:397/22)
  Kommentar till text 21650 av Robert Bashe (2:2448/44)
Ärende: Legal Strictions
========================
08 Oct 08 08:25, Robert Bashe wrote to Roy Witt:

 RB> Roy Witt wrote to shannon talley on Tuesday October 07 2008 at 13:24:

 st>>> There is a British medical study that indicates that Marijuana has
 st>>> less considerably less tar than Tobacco.

 RW>> There are 'real' studies where the amount is more than tobacco. One
 RW>> can get what one wishes to get in any study.

 RB> That depends on who finances the study. Do you know of any that are
 RB> financed by marijuana growers?

If you read the blogs on it, there are some very knowledgable people
writing their. One such blog had a question presented by a 'grower'; Is it
possible to inject marijuana? Here's an educated reply.

"The bit that BilZ0r posted about making up an injection of THC for IV use
mentions Tween-80, which as he said, is a surfactant. These are used to
produce emulsions for injection, they do not increase THC's solubility in
water. Another drug that comes as an emulsion for IV use is diazemuls,
which, as you might guess by the name, an injectible form of diazepam
(that prep uses fractionated soya oil).

That said, if you don't have a background in pharmaceutical preparations,
trying to make your own is just a disaster waiting to happen. There is a
synthetic analogue of THC, in which the carbon at the top of the ring
containing the double bond has been replaced by a nitrogen (also ring is
totally saturated), to allow the formation of water soluble salts for
injection. Apparently it's quite potent, but you're more likely to see
pigs fly and dogs talk than come across any of that (think it was from
McNeil Labs).

To Dr. McBudstoke
The esters you propose wouldn't make it water soluble as they are
effectivly just long hydrocarbon chains (and not water soluble), but an
ester from something like 2-dimethylaminoacetic acid might have a fighting
chance of being water soluble.

You could always make up an oily injection and use a deep IM route (as
they do for depot injections of antipsychotics).

A depot injection of THC??? Don't know if I want to be stoned for 3 weeks
straight though!


PS. BilZ0r, you should apply to GW Pharmaceuticals for a research
funding/post (the ones doing the cannabis trials for the UK government).
You'd get to do research with an interesting group of compounds
(cannabinoids) AND get paid a proper working wage, unlike the pittances
they hand out to live on along with the research funding (that's what
eventually ended my career - a desire for a decent wage), esp if there
isn't any pharmaceutical firm interested in your area of research."

It seems that this dude has been around the research labs for a while.

                R\%/itt



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